Hotels in Santee

Best Santee Hotels

Enter your dates for prices and availability of the best hotels in Santee.

Swipe down to view more
Filter by:
Hotel Star Rating
≤2345
Guest Rating
Amazing 9+Great 8+Good 7+Pleasant 6+
Popular filters for Santee
Breakfast includedPets welcomeVery Good 8+1 double bedHotelPay at Hotel
Property Type
HotelMotel
Property facilities & services
Pets welcome24-hour front deskFree parkingParking availableWi-Fi in public areasSmoking areaGolf coursePoolGymConference roomRestaurantElevatorWake-up callLuggage storageBarBarbecueEV charging stationWater park

13 Best Hotels to Stay in Santee

Find great hotels in Santee on Trip.com! Read guest reviews, compare the latest prices, and explore hotel details to choose your perfect stay.
Most Booked
Lowest price
Closest to downtown
Highest Rated
Comfort Inn & Suites Santee I-95 Hotels in Santee
Comfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in SanteeComfort Inn & Suites Santee I-95 Hotels in Santee
56
Hotels in Santee
Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 24.5 mi (39.5 km) from Congaree National Park and 1.2 mi (1.9 km) from Santee Town Hall. Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine. A complimentary buffet breakfast is included. Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite. Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.
Very Good
100 reviews
8.0/10
1 night
From SAR 442
Check availability
Tru by Hilton Santee Hotels in Santee
Tru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in SanteeTru by Hilton Santee Hotels in Santee
51
Hotels in Santee
"Every time I drive back to New York from Florida, I will live here. It is convenient and clean. It also accepts pets. There is no microwave in the room. But there is a front desk downstairs. It is still very recommended."
Very Good
101 reviews
8.7/10
1 night
From SAR 414
Check availability
Baymont by Wyndham Santee Hotels in Santee
Baymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in SanteeBaymont by Wyndham Santee Hotels in Santee
53
Hotels in Santee
"We are pleased our stay at Baymont Windham in Santee,SC. Clean room, good service, ideal location next to 95,."
Good
102 reviews
7.7/10
1 night
From SAR 282
Check availability
Travelodge by Wyndham Santee Hotels in Santee
Travelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in SanteeTravelodge by Wyndham Santee Hotels in Santee
30
Hotels in Santee
"Ummmm wrong room given at start Breakfast was pieces of pastry cut up...o.o Coffee was beyond burnt Least it had a room to be safe from the elements"
99 reviews
6.8/10
1 night
From SAR 241
Check availability
Fairfield Inn & Suites Santee Hotels in Santee
Fairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in SanteeFairfield Inn & Suites Santee Hotels in Santee
49
Hotels in Santee
"The breakfast was okay, but the waiter had a mediocre attitude. The hotel is clean and tidy and comfortable. The location of the hotel is also good, basically every time I come back to Florida from the north, I will stay here for one night. Parking is free."
Amazing
107 reviews
9.7/10
1 night
From SAR 541
Check availability
Best Western Plus Santee Inn Hotels in Santee
Best Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in SanteeBest Western Plus Santee Inn Hotels in Santee
48
Hotels in Santee
"There is an Asian restaurant across the street. It tastes good. I can enjoy such a comfortable meal in the south. I feel very satisfied. Very close to the lake, just a few minutes drive. The hotel is a standard budget motel!"
Very Good
99 reviews
8.4/10
1 night
From SAR 462
Check availability
Hampton Inn Santee Hotels in Santee
Hampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in SanteeHampton Inn Santee Hotels in Santee
99+
Hotels in Santee
"The breakfast was good and the food was good. The rooms are large and the service is warm. be quiet. There are many restaurants around to eat, which is very convenient. Huanpeng's brand is not bad, the price is moderate, suitable for rest in the middle of the journey."
Amazing
97 reviews
9.4/10
1 night
From SAR 502
Check availability
Red Roof Inn Santee Hotels in Santee
Red Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in SanteeRed Roof Inn Santee Hotels in Santee
47
Hotels in Santee
Red Roof Inn Santee offers a budget-friendly stay in the heart of "America's Value Golf Destination." Whether you're here for championship golf, lake recreation, or exploring the area, Red Roof Inn Santee provides dependable comfort and value in beautiful Santee, South Carolina. Red Roof Inn Santee is a welcoming and affordable choice for golf enthusiasts and families seeking relaxation near Lake Marion. With friendly service and thoughtful amenities, we make every stay simple and enjoyable. Guests can expect a pleasant stay with essentials, including free Wi-Fi, a free expanded cable package featuring HBO, a complimentary continental breakfast, and coffee in the lobby. Each room also features a microwave and mini-refrigerator for added convenience. We are proud to be a pet-friendly hotel, so your four-legged companion is always welcome. Our Santee, SC hotel is located near popular attractions such as Lake Marion Golf Course, Santee Cooper Country Club, Lake Marion, Santee State Park, the Santee National Wildlife Refuge, and the Santee Conference Center, all within easy reach.
88 reviews
6.4/10
1 night
From SAR 237
Check availability
Holiday Inn SANTEE by IHG Hotels in Santee
Holiday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in SanteeHoliday Inn SANTEE by IHG Hotels in Santee
92
Hotels in Santee
The Holiday Inn Santee hotel is perfect for recreational activities. Just off I-95 in Santee, SC, our hotel's location is less than an hour from both Columbia and Charleston, two unique cities to visit for a day trip. For those looking for a little relaxation, there is plenty to do in Santee. Our hotel's guests can enjoy the numerous golf courses that dot this area. Visitors also tend to gravitate towards Lake Marion for fishing, as this area is famous for its striped bass and huge catfish. The beautiful lake is supplemented by the glorious, blooming flowers and the clouds of colorful, flitting butterflies that you can find at the Edisto Memorial Gardens. Those on business trips also find it very easy to get things done in Santee, SC. The hotel's proximity to a number of golf courses can provide a peaceful backdrop for intense meetings and business lunches. The 24-hour Business Center and free Internet access are provided to help you make the most of your time. After a day out on the lake or on the golf courses, come back and enjoy some comfort food in the hotel's restaurant. Let the heated pool work for you after a long day of meetings or play. "Southern hospitality" isn't just a slogan for us; it's our guarantee for great, friendly service. Make your reservation today to experience our brand of South Carolina charm!
Very Good
99 reviews
8.0/10
1 night
From SAR 370
Check availability
Ramada by Wyndham Santee I-95 Hotels in Santee
Ramada by Wyndham Santee I-95 Hotels in SanteeRamada by Wyndham Santee I-95 Hotels in SanteeRamada by Wyndham Santee I-95 Hotels in SanteeRamada by Wyndham Santee I-95 Hotels in SanteeRamada by Wyndham Santee I-95 Hotels in SanteeRamada by Wyndham Santee I-95 Hotels in Santee
34
Hotels in Santee
Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.
52 reviews
6.3/10
1 night
From SAR 314
Check availability
See All Hotels in Santee

Trip.com's insights for hotels in Santee

Plan smarter with Trip.com’s data-backed insights on travel seasons, so you can book your Santee hotel at the right time.

What is the cheapest day of the week for hotels in Santee?

Thursday offers the lowest average hotel rates in Santee at around SAR 452 per night, while Tuesday tends to be the most expensive, averaging SAR 562 per night.
(Based on Trip.com data from May 24, 2025 to May 24, 2026.)
Mon
Tue
Wed
Thu
Fri
Sat
Sun

Find your unique stays in Santee

Immerse yourself in the vibrant atmosphere of Santee with our handpicked accommodation options

Most-booked Santee hotels

See all
Check out these top-booked hotels from the past 30 days!
Quality Inn & Suites Hotels in Santee
6.0/10
100 reviews

Quality Inn & Suites

Hotel near Santee
Top choice among guests booking hotels in Santee
Located in Santee, Quality Inn & Suites Santee I-95 is within a 15-minute walk of Santee Cooper Country Club and Santee State Park. This hotel is 24.9 mi (40.1 km) from Congaree National Park and 1.1 mi (1.7 km) from Santee National Golf Club. Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless internet access and a fireplace in the lobby. Additional features at this hotel include a banquet hall and a vending machine. Grab a bite to eat at one of the hotel's many dining establishments, which include 7 restaurants and a coffee shop/cafe. Quench your thirst with your favorite drink at the bar/lounge. A complimentary full breakfast is served daily from 6:30 AM to 9:30 AM. Featured amenities include a computer station, a 24-hour front desk, and multilingual staff. Free self parking is available onsite. Make yourself at home in one of the 106 air-conditioned rooms featuring LED televisions. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.
Select dates to view prices
Super 8 by Wyndham Santee Hotels in Santee
6.7/10
70 reviews

Super 8 by Wyndham Santee

Hotel near Santee
Top choice among guests booking hotels in Santee
Make our Super 8 Santee hotel your home base for golf and recreation in South Carolina. Located off I-95 halfway between New York City and Miami our hotel is a comfortable stopping point on your East Coast road trip.
Select dates to view prices
Econo Lodge Hotels in Santee
6.3/10
18 reviews

Econo Lodge

Hotel near Santee
Top choice among guests booking hotels in Santee
A stay at Econo Lodge Santee places you in the heart of Santee, a short 4-minute walk from Santee Cooper Country Club and within 3 minutes by car from Santee National Golf Club. This hotel is 25.6 mi (41.1 km) from Congaree National Park and 1.4 mi (2.2 km) from Santee State Park. Take in the views from a garden and make use of amenities such as complimentary wireless internet access and barbecue grills. Featured amenities include a 24-hour front desk and luggage storage. Free self parking is available onsite. Make yourself at home in one of the 37 guestrooms featuring refrigerators and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and microwaves, as well as phones with free local calls.
Select dates to view prices

FAQs About Santee Hotels

Where can I find the best hotels in Santee?

Santee has some of the best hotels for you to select. Whether you're traveling for business or on a vacation, Fairfield Inn & Suites Santee (from SAR 517), Tru by Hilton Santee (from SAR 376) and Best Western Plus Santee Inn (from SAR 452) are preferred hotels.

What's the best pet-friendly accommodation in Santee?

Tru by Hilton Santee (from SAR 376) allows pets. Take your pets with you during your stay!

What are some hotels with pools in Santee?

Fairfield Inn & Suites Santee (from SAR 517), Tru by Hilton Santee (from SAR 376) and Best Western Plus Santee Inn (from SAR 452) are hotels with swimming pools. Stay at any of these hotels to enjoy a swimming pool!

Where can you find hotels with excellent breakfast in Santee?

Fairfield Inn & Suites Santee (from SAR 517),Tru by Hilton Santee (from SAR 376) and Best Western Plus Santee Inn (from SAR 452) provide high-quality breakfast. Start your day with fresh, delicious breakfast!

Where can I find the best hotel discounts in Santee?

Trip.com provides various promotions and discounts for users all year round. You can check the promotions page to see what promotions are available on Trip.com.

Santee Hotels Info

Number of reviews
1,132
Total properties
13
Weekday Avg. Price
SAR 433
Weekend Avg. Price
SAR 528
Trending hotel
Fairfield Inn & Suites Santee