Mytilene

Boutique Hotels in Mytilene

Select your dates to find cozy boutique hotels in Mytilene with a charming local feel.

Swipe down to view more
Filter by:
Hotel Star Rating
≤2345
Guest Rating
Amazing 9+Great 8+Good 7+Pleasant 6+

Top Boutique Hotels Mytilene

Discover the best boutique hotels in Mytilene, celebrated for their unique style and personality.
Most Booked
Lowest price
Closest to downtown
Highest Rated
99+

Theofilos Paradise Boutique Hotel

Hotels in Mytilene
Featured facilities: Pool, Bar
Great
45 reviews
9.2/10
1 night
From JPY 14,243
Check availability
99+

The Loriet

Hotels in Varia
Featured facilities: Pool, Bar, Restaurant
Very Good
59 reviews
8.4/10
1 night
From JPY 10,652
Check availability
64

PIERRES BLANCHES WITH PRIVATE POOLS

Hotels in Mytilene
Featured facilities: Private pool
Outstanding
72 reviews
9.9/10
Check availability
99+

Elysion Hotel

Hotels in Mytilene
Featured facilities: Pool, Cafe, Bar
Great
20 reviews
9.0/10
1 night
From JPY 14,865
Check availability
99+

Mythical Coast Wellness Retreat

Hotels in Mytilene
Featured facilities: Pool view, Cafe, Restaurant
Very Good
73 reviews
8.0/10
1 night
From JPY 13,572
Check availability
See All Boutique Hotels in Mytilene

What's new in Mytilene

Updated on November 15, 2026
A weather alert for Mytilene warns of locally intensive rain and thunderstorms, with 15 to 18 mm of precipitation forecast in 12 hours. Expect possible localized flooding of properties and disrupted outdoor activities. Driving conditions may be difficult due to reduced visibility and aquaplaning. Exercise extra caution in exposed areas, including mountains, forests, and open terrain.

FAQs

What is the average price of a hotel in Mytilene for this weekend?

According to the latest 12-month data from Trip.com, the average price for a 3-star hotel in Mytilene this weekend is JPY 18,912 per night. For a 4-star hotel, the average cost is JPY 27,151 per night. If you're looking for a luxury experience, 5-star hotels in Mytilene this weekend typically cost JPY 27,911 per night.

How much do hotels in Mytilene cost per night during weekdays?

Based on the latest 12-month data from Trip.com, the average price for a 3-star hotel in Mytilene during weekdays is JPY 18,593 per night. For a 4-star hotel, you can expect to pay around JPY 27,043 per night. If you're seeking a luxury stay, 5-star hotels in Mytilene generally cost JPY 28,150 per night on weekdays.

What are the best places to stay in Mytilene?

Some of the best places to stay in Mytilene are near popular attractions like Mytilini Port and University of the Aegean, offering easy access to key sights and amenities.

What are the best family-friendly hotels in Mytilene?

Families visiting Mytilene often prefer hotels like Blue Sea Hotel (from JPY 11,418), Lesvion Hotel (from JPY 10,556) and Mythical Coast Wellness Retreat (from JPY 14,434), which are well-known for their family-friendly features of spacious family rooms and child-friendly services.

What are the top hotels in Mytilene near Mytilini Port?

Some of the top hotels in Mytilene near Mytilini Port include Blue Sea Hotel (from JPY 11,418), Theofilos Paradise Boutique Hotel (from JPY 15,966) and Lesvion Hotel (from JPY 10,556), all offering easy access to Mytilini Port, making them ideal for visitors looking to explore the area.

What's the best pet-friendly accommodation in Mytilene?

Theofilos Paradise Boutique Hotel (from JPY 15,966), Heliotrope the Studios (from JPY 11,250) and The Loriet (from JPY 10,747) allow pets. Take your pets with you during your stay!

What’s the best hotel in Mytilene with hot springs?

Wanna experience hot springs in your hotel? Mythical Coast Wellness Retreat (from JPY 14,434) and Theofilos Paradise Boutique Hotel (from JPY 15,966) have hot springs. Book now!

Where can I find the best hotel discounts in Mytilene?

Trip.com provides various promotions and discounts for users all year round. You can check the promotions page to see what promotions are available on Trip.com.