Hotels near Route 66, San Francisco
Enter your dates for the latest hotel rates and availability.
Swipe up to view more
Filter by:
Hotel Star Rating
≤2345
Guest Rating
Amazing 9+Great 8+Good 7+Pleasant 6+Best Hotels near Route 66
Choose your travel dates to see the latest prices and deals.
Most Booked
Lowest Price
Closest to Downtown
Highest Rated
San Francisco Downtown | 2.37km from Route 66
The Hotel Nikko San Francisco provides a great place for travelers to relax after a busy day. Visitors to San Francisco will find that the Hotel Nikko San Francisco is a fantastic accommodation choice. The hotel is conveniently located just 1km from Embarcadero and 22km from San Francisco International Airport. Transportation around the city is also convenient, with Powell Street Metro Station within walking distance. With multiple attractions nearby including Children's Creativity Museum, Yerba Buena Center for the Arts and Union Square, guests will find plenty to keep themselves occupied. This hotel makes a great place to kick back and relax after a long day of sightseeing. Guests of this San Francisco hotel can make use of the parking facilities. Germaphobes can rest easy - the level of cleanliness is highly rated at this hotel. For guests traveling with families, this hotel is consistently one of the most popular choices.
Great
161 reviews
9.2/10
Price from
US$186
per night
San Francisco Downtown | 2.26km from Route 66
The Handlery Union Square Hotel provides a great place for travelers to relax after a busy day. The Handlery Union Square Hotel is an ideal choice for travelers who want to take in the sights and sounds of San Francisco. With Embarcadero just 1km away and San Francisco International Airport only 22km away, transportation is very convenient. In addition, Powell Street Metro Station is just a short walk away. Seeing San Francisco's sights from this hotel is easy with Nob Hill, Transamerica Pyramid and Sandbox VR all close by. This hotel makes a great place to kick back and relax after a long day of sightseeing. This San Francisco hotel provides parking on site. If you are looking for a convenient place to stay, our guests have told us that this location is excellent.
Very Good
63 reviews
8.9/10
Price from
US$162
per night
San Francisco Downtown | 2.38km from Route 66
The Hilton San Francisco Union Square provides a great place for travelers to relax after a busy day. The Hilton San Francisco Union Square offers a pleasant stay in San Francisco for those traveling for business or leisure. The hotel is only 1km from Embarcadero and 22km from San Francisco International Airport, giving guests a number of convenient transportation options. Transportation around the city is also convenient, with Powell Street Metro Station within walking distance. This hotel is located near many of San Francisco's attractions including Union Square, Sandbox VR and Children's Creativity Museum. This hotel makes a great place to kick back and relax after a long day of sightseeing. This San Francisco hotel provides parking on site. For guests traveling with families, this hotel is consistently one of the most popular choices.
Very Good
216 reviews
8.4/10
Price from
US$137
per night
You Might Like
San Francisco Hotels With BreakfastSan Francisco Hotels With Twin RoomSan Francisco Hotels With 1 Double BedSan Francisco Hotels With Swimming PoolSan Francisco Hotels With Free Cancellation
San Francisco Downtown | 2.5km from Route 66
The Parc 55 San Francisco - a Hilton Hotel is an ideal spot for travelers wanting to discover the city. The Parc 55 San Francisco - a Hilton Hotel is an ideal choice for travelers who want to take in the sights and sounds of San Francisco. The hotel is only 1km from Embarcadero and 22km from San Francisco International Airport, giving guests a number of convenient transportation options. Being just minutes away from Powell Street Metro Station allows guests to explore the city with ease. Seeing San Francisco's sights from this hotel is easy with Yerba Buena Center for the Arts, Asian Art Museum and Union Square all close by. After a long day of sightseeing, guests can retire to the comfort of the hotel. Our guests rate this hotel as one of the best hotels for cleanliness. This hotel is particularly popular with those traveling with families.
Very Good
238 reviews
8.8/10
Price from
US$114
per night
San Francisco Downtown | 1.74km from Route 66
Enjoy the very latest in state-of-the-art amenities and unparalleled service during your stay at Stanford Court. Re-imagined for the savvy digital age traveler, the hotel features newly redesigned rooms and spaces, spectacular Nob Hill views and a convenient location for exploring the best of SF. Your Wellbeing is Our Top Priority! In response to COVID-19, we have initiated and are maintaining industry-leading and scientifically driven elevated cleanliness standards to safeguard the wellbeing of our guests and colleagues. Our strengthened safety and sanitizing measures incorporate the latest guidance from the world’s leading health authorities, including the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO), and apply to all guest rooms, public and back-of-house areas. Hotel adheres to AHLA Cleaning Standards. For details on cleaning and health policy visit hotel website.
Very Good
120 reviews
8.9/10
Price from
US$152
per night
Fisherman's Wharf | 0.14km from Route 66
The Hotel Zoe Fishermans Wharf is an ideal spot for travelers wanting to discover the city. Visitors to San Francisco will find that the Hotel Zoe Fishermans Wharf is a fantastic accommodation choice. The hotel is only 3km from Embarcadero and 25km from San Francisco International Airport, giving guests a number of convenient transportation options. This hotel is located near many of San Francisco's attractions including PIER 39, Cable Car Museum and USS Pampanito Museum and Memorial. At the end of a busy day, travelers can unwind and relax in the hotel or go out and enjoy the city. Guests of this San Francisco hotel can make use of the parking facilities. Our guests rate this hotel as one of the best hotels for cleanliness.
Very Good
139 reviews
8.9/10
Price from
US$115
per night
Marina District | 2.06km from Route 66
With a stay at Cow Hollow Inn & Suites in San Francisco (Marina District), you'll be within a 5-minute drive of Presidio of San Francisco and Alcatraz Island. This hotel is 2.1 mi (3.3 km) from Pier 39 and 2.4 mi (3.9 km) from Golden Gate Bridge.
Make use of convenient amenities such as complimentary wireless internet access, concierge services, and a vending machine.
Enjoy a meal at the restaurant or snacks in the hotel's coffee shop/cafe. Cooked-to-order breakfasts are available daily from 7:00 AM to 1:00 PM for a fee.
Featured amenities include dry cleaning/laundry services, a 24-hour front desk, and multilingual staff. Free self parking is available onsite.
Stay in one of 129 guestrooms featuring flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with shower/tub combinations feature complimentary toiletries and hair dryers. Conveniences include safes and desks, as well as phones with free local calls.
Very Good
169 reviews
8.4/10
Price from
US$121
per night
San Francisco Downtown | 2.68km from Route 66
Located on Market Street, our hotel is half a mile from Union Square. Explore nearby museums, catch a show in the theater district, and enjoy the curated local art collection throughout our hotel. Our rooftop restaurant and bar feature beautiful views of downtown San Francisco as well as small plates and craft cocktails.
Very Good
74 reviews
8.7/10
Price from
US$103
per night
San Francisco Downtown | 2.11km from Route 66
The Fitzgerald Hotel is a great choice for guests looking for accommodation in San Francisco, having been recently opened in 2023. Traveling to the hotel is easy with Embarcadero located approximately 2km away and San Francisco International Airport roughly 22km away. Transportation around the city is also convenient, with Powell Street Metro Station within walking distance. This hotel is located near many of San Francisco's attractions including Japantown, Grace Cathedral and Cathedral of Saint Mary of the Assumption. After a long day of sightseeing, guests can retire to the comfort of the hotel. This hotel is particularly popular with those traveling with families.
Very Good
132 reviews
8.1/10
Price from
US$83
per night
San Francisco Downtown | 2.24km from Route 66
The Clift Royal Sonesta San Francisco is a great choice for guests looking for accommodation in San Francisco, having been recently renovated in 2022. Traveling to the hotel is easy with Embarcadero located approximately 1km away and San Francisco International Airport roughly 22km away. In addition, Powell Street Metro Station is just a short walk away. With multiple attractions nearby including Sandbox VR, Cable Cars and Japantown, guests will find plenty to keep themselves occupied. When guests have some time on their hands they can make use of the onsite facilities. If cleanliness is important to you, this hotel makes an excellent choice, as our guests consider this to be one of the cleanest hotels in the city. This hotel is a popular accommodation for guests traveling with families.
Great
127 reviews
9.2/10
Price from
US$147
per night
Top 5 Premium Hotels in San Francisco
See all
Discover our curated selection of premium hotels in San Francisco for your next stay
No.
1
9.7/10
48 reviewHotel Drisco
Hotel near Pacific Heights, San Francisco
"Good Location"
Select dates to view prices
No.
2
9.1/10
110 review1 Hotel San Francisco
Hotel near South of Market, San Francisco
"Good Location"
Select dates to view prices
No.
3
9.0/10
92 reviewThe St. Regis San Francisco
Hotel near South of Market, San Francisco
"Great service"
Select dates to view prices
No.
4
9.0/10
123 reviewPalace Hotel, a Luxury Collection Hotel, San Francisco
Hotel near South of Market, San Francisco
"Great stay!""Great rooms"
Select dates to view pricesNo.
5
8.3/10
120 reviewFairmont San Francisco
Hotel near San Francisco Downtown, San Francisco
"Great stay!""Great rooms"
Select dates to view pricesTop Pick Hotels near Route 66
See all
Discover our most booked hotels near Route 66 from the last 30 days!
No.1
8.8/10
156 reviewRiu Plaza Fisherman's Wharf
Fisherman's Wharf, San Francisco | 0.21KM from Route 66
"Delicious breakfast""Great location"
Select dates to view pricesNo.2
8.5/10
66 reviewHotel Caza Fisherman’s Wharf
Fisherman's Wharf, San Francisco | 0.2KM from Route 66
"Great stay!""Convenient location"
Select dates to view pricesNo.3
8.6/10
134 reviewHotel Zephyr Fishermans Wharf San Francisco
Fisherman's Wharf, San Francisco | 0.24KM from Route 66
"Great location""Friendly host"
Select dates to view pricesNo.4
8.9/10
131 reviewHoliday Inn Express & Suites San Francisco Fishermans Wharf
Fisherman's Wharf, San Francisco | 0.06KM from Route 66
"Great location""Great rooms"
Select dates to view pricesNo.5
7.6/10
124 reviewThe Wharf Inn
Fisherman's Wharf, San Francisco | 0.17KM from Route 66
"Good Location"
Select dates to view pricesNo.6
9.1/10
86 reviewKimpton Alton Fisherman's Wharf
Fisherman's Wharf, San Francisco | 0.13KM from Route 66
"Great location""Great service"
Select dates to view pricesNo.7
9.0/10
55 reviewMarriott Vacation Club Pulse, San Francisco
Fisherman's Wharf, San Francisco | 0.18KM from Route 66
"Great location""Great rooms"
Select dates to view pricesNo.8
8.5/10
80 reviewHyatt Centric Fishermans Wharf
Fisherman's Wharf, San Francisco | 0.07KM from Route 66
"Great location""Great service"
Select dates to view pricesNo.9
8.3/10
135 reviewClub Quarters Hotel in San Francisco
San Francisco Downtown, San Francisco | 1.82KM from Route 66
"Great location""Clean and tidy"
Select dates to view pricesNo.10
8.4/10
171 reviewHilton San Francisco Financial District
San Francisco Downtown, San Francisco | 1.64KM from Route 66
"Clean and tidy""Great location"
Select dates to view pricesLatest reviews for San Francisco hotels
See all
Read genuine traveler ratings & reviews to find your perfect stay.
9.2/10
Great
AA_ Madi6That’s my second stay at CitizenM hotel. The first one was at LA and this one in SF. Really it’s my first choice due to the quality of the services.
It will be better if they let people do self check in without interrupting them.
9.1/10
Great
FFrench DudeI recently stayed at the Galleria Park Hotel during my business trip to San Francisco and here are my thoughts:
Location:
The location of the hotel is quite good. Although the area is quiet at night, there are many places to visit during the day. The neighborhood is very central, not far from Chinatown, just a 15-minute walk away.
Security:
The security at the hotel is excellent. It is very secure and they do not let just anyone enter.
Credit Card Policy:
A major downside, not directly related to the hotel itself, is the strict credit card policy. Even though I paid everything online, presenting a credit card at check-in is mandatory. Without it, you might end up sleeping outside. Additionally, at check-out, there's an unexpected mandatory state tax charged to your card, which you are not informed about beforehand. This is a compulsory tax for the state of California.
Room:
The room was decent. It had a small fridge, but nothing for brushing your teeth. I don’t know if it’s typical of American hotels, but I find showers without hand showers inconvenient. The bed was comfortable. I have some doubts about the cleanliness of the thick carpet, though it seemed clean. Instead of curtains, there are blinds on the windows, which I found disappointing.
Breakfast:
I was disappointed that there was no breakfast provided. Only coffee is offered in the morning and wine in the afternoon, but honestly, I don't care for the wine. We need food. I had to walk 15 minutes to a Seven Eleven to get something to eat and drink.
Wi-Fi:
The Wi-Fi was quite good and worked very well.
Overall, the Galleria Park Hotel has some good points, but there are several areas where it could improve.
8.9/10
Very Good
GGuest UserVery expensive for a B&B. Nice spot in the Castro/ Mission district near Dolores Park. Well-maintained & reasonable management. Lots of stairs to go up into main house lobby — wrought iron gates with intercom to buzz to get entry into property. Try to get a room in the older main house to minimize stairs! No AC. They have limited parking spots behind the two B&B houses (access from Dorland St) for US$35./day plus tax which is a steep price. Make sure u book a parking spot in advance. Beautiful garden courtyard in the back. Sadly we never got to use it. Try to get a room that faces the other “house” or the backyard - quieter. We had a front room Deluxe King Room 36 which looked nothing like the sample room photos (only one Room 24 w courtyard view, sofa, coffee table). We got a smaller room approx 290sf vs what we paid for 32sq.m, 344sf, no closet just small armoire to hang a couple of things, no sofa, no coffee table, no balcony. They were kind enough to give us a refund for the price difference between the Deluxe King we booked & the Standard King we got. Had to ask for them to vacuum room. Found tissue under headboard/bed, dusty. Not the kind of room you would want to spend much time in —teeny tiny TV, faced front noisy street with electric bus passing by. No screens in windows so had to close windows at night to keep critters out. Bed was ok. Pillows were synthetic & lumpy. View was of electric lines & school across the street. Beware some electric outlets. One was burnt out. Breakfast was repetitive but nice to eat in a lovely breakfast room or outdoor deck. Hard-boiled eggs, muesli, fruit, muffins/ carbs, American coffee, juices. Fortunately SPRO café was next door if you need a great cappuccino or chai latté! Didn’t get a chance to enjoy their wine & cheese. Contact them on WhatsApp +1 (415) 297-6891 to discuss rooms available.
8.9/10
Very Good
FFrederickyeoI like the hotel.
Located at a wonderful location just right across the cable car stop. The room was cozy and comfortable. The bed was nice and comfy. There are safe, ice bucket and coffee machine. And the bathroom was spacious.
I will very much recommend this hotel.
8.8/10
Very Good
AAnonymous UserHotel Spero offers a charming boutique stay in San Francisco with stylish decor, friendly staff, and eco-friendly touches. Rooms are cozy, and the location is convenient but can be busy. At Jasper, the hotel’s restaurant, the yogurt parfait is a fresh and light breakfast option with creamy yogurt, berries, and granola. A great choice for comfort and character.
8.8/10
Very Good
YYOKE KWAIGreat location. The hotel is in downtown San Francisco and with cable cars just outside the front door. There was a strike ongoing by the workers. The workers protesting outside and banging drums. The hotel looks old but the room is clean and comfortable. The staff is friendly and helpful.
The Westin St. Francis San Francisco on Union Square
San Francisco Downtown, San Francisco
Price per night from:US$155
8.7/10
Very Good
Ccarrie2000This hotel feels very good, the layout and facilities of the hotel are very atmospheric, the service attitude is very good, the surrounding environment is also good, supermarkets, restaurants, and transportation are very convenient.
7.5/10
GGuest UserAll of the staff seemed really nice. From the moment we arrived and had a friendly greeting from the valet parking worker, to the ladies that we interacted with in reception.
The room was nothing special, but by that I mean it had no outstanding features, or any distinguishable traits that would separate it from other hotels
The concierge was friendly and helpful, and was very useful in helping us to plan our activities.
And the hotel is in a good location to get to the pier or do the 'big bus' tour.
But here's the downside. The gym is small, had no steriliser, or wipes, even though one of the rules stated in the gym is to wipe down the equipment after use.
And the overall impression of the gym is that it could do with a really good clean from top to bottom.
Added to that there's the washing machine and tumble dryer located in the gym.
Yes that's right, in the actual gym.
Now we were very happy when we read about the hotel having washing machine facilities, but we were slightly surprised at it's location.
Another thing was the air con. We stayed in September and although the weather for the season was just starting to cool down after the summer, it was still fairly warm.
The air con looked as if it had been fitted in the seventies and made a sound as if it had been running non stop ever since then.
It was so noisy that we had to turn it off completely at night time and at different times during the day.
On a final point we received news regarding the death of my partner's daughter, which meant that we had to cut our whole vacation short including this leg of the trip.
We informed the front desk that we would be checking out one day early.
We were not expecting a refund, for that day, but after being told by the member of staff that the 30 dollar a night 'destination fee' would be waived for the night that we were not going to be there, we later found out that this fee had still been added to the final bill.
We still have no idea what a 'destination fee' is, but to be charged it when we weren't even at the hotel was extra galling.
And what was also strange was the fact they didn't even ask why it was that we had decided to cut our stay short?
Would you not be interested to know whether something was wrong with your customers stay, and to know why they had cut their visit short??
A bit of a poor end to a otherwise 'ok' stay at the hotel.
7.2/10
LLIHONGThe hotel should be newly installed but the room has no smell. The room looks clean and tidy. It has its own parking lot. It does not touch the Chinese people. There are many Americans living in the hotel. The hotel is safe. The subway station is also close. Walk to Union Square for about 1.5km. , location can be. No early, there is Chinese food downstairs, there is a match on the opposite side, the attitude at the front desk is acceptable. Homeless outside the hotel is a little scary, try to travel as little as possible at night, it is quite difficult to avoid it completely at SanFrancisco, and there seems to be less near the Fisherman's Wharf. . . There seems to be three taxes in this hotel. . .
6.4/10
SSHUMEIHotel location is very good, in Union Square, walking to the Lombard Street, Fisherman's Wharf, but the city of San Francisco is a lot of tramps, marijuana taste is really disgusting. Hotel health is OK, although the price is not low but can not be measured by domestic price standards, the old elevator is also a bit special.
Frequently asked questions
Which hotels near Route 66 are the most popular?
Hotel Zoe Fishermans Wharf (from US$88),Riu Plaza Fisherman's Wharf (from US$132) and Hotel Caza Fisherman’s Wharf (from US$126) are the most popular hotels.
What luxury hotels are near Route 66?
InterContinental Mark Hopkins San Francisco (from US$163), Fairmont San Francisco (from US$190) and Grand Hyatt San Francisco Union Square (from US$168) are the most popular luxury hotels.
What hotels near Route 66 offer breakfast?
A perfect breakfast gives you energy for the day. If you want to stay at a hotel near San Francisco Route 66 with a high-quality breakfast, you can consider staying Hotel Zoe Fishermans Wharf (from US$88),Hotel Caza Fisherman’s Wharf (from US$126) and Riu Plaza Fisherman's Wharf (from US$132) .These hotels are very popular, so book early.
Which hotels near Route 66 have free Wi-Fi?
Hotel internet access is especially important for independent travelers and business travelers. Hotel Zoe Fishermans Wharf (from US$88),Hotel Caza Fisherman’s Wharf (from US$126) and Riu Plaza Fisherman's Wharf (from US$132) are popular hotels with free Wi-Fi.
Which hotels near Route 66 have gyms?
In recent years, public awareness for body health has increased, so many hotels have fitness rooms. Riu Plaza Fisherman's Wharf (from US$132),Hotel Caza Fisherman’s Wharf (from US$126) and Hotel Zephyr Fishermans Wharf San Francisco (from US$112) are popular hotels with a fitness room.
Which popular hotels near Route 66 have parking?
If you're planning a road trip to San Francisco and Route 66, consider staying at Hotel Zoe Fishermans Wharf (from US$88),Riu Plaza Fisherman's Wharf (from US$132) and Hotel Caza Fisherman’s Wharf (from US$126) . These are popular hotels with parking lots.
What hotels are recommended near Route 66?
If you're having trouble choosing a hotel, you might want to consider staying at Hotel Zoe Fishermans Wharf (from US$88),Riu Plaza Fisherman's Wharf (from US$132) and Hotel Caza Fisherman’s Wharf (from US$126) . These hotels are highly rated, so you should book early.
Which popular hotels near Route 66 have pools?
Many people travel to San Francisco Route 66 for a family road trip during the summer or long holidays. Hotel Caza Fisherman’s Wharf (from US$126), Riu Plaza Fisherman's Wharf (from US$132) and Hyatt Centric Fishermans Wharf (from US$141) are popular hotels with pools where you can relax and enjoy the summer vibe.
San Francisco weather
Today
28 Aug, 2025
14
°
Mostly clear 14 - 22℃
28 Aug, 2025
Mostly clear14 - 22℃
29 Aug, 2025
Intermittent clouds15 - 21℃
30 Aug, 2025
Partly clear14 - 21℃
31 Aug, 2025
Mostly clear16 - 26℃
1 Sep, 2025
Clear15 - 24℃
2 Sep, 2025
Intermittent clouds14 - 19℃
3 Sep, 2025
Intermittent clouds14 - 18℃
San Francisco Hotels near Route 66 Information
| Highest Price | US$4,684 |
|---|---|
| Lowest Price | US$46 |
| Number of Reviews | 22,821 |
| Total Properties | 242 |
| Average Price (Weekdays) | US$332 |
| Average Price (Weekends) | US$289 |
Keep Exploring
San Francisco Hotels near Attractions
Most Popular Hotels in San Francisco
Hilton San Francisco Union SquareTimbri Hotel San Francisco, Curio Collection by HiltonThe Ritz-Carlton, San FranciscoHandlery Union Square HotelChapter San FranciscoHotel Spero, Vignette CollectionAxiom HotelHotel EpikThe Barnes San Francisco, Tapestry Collection by HiltonThe Fitzgerald HotelHotels near Garden-Park @ Taraval & Great HwyHotels near Ying On Labor & Merchant Association BuildingHotels near California Historical Landmark 861: Site of First California State FairHotels near The Wine HouseHotels near Rossi Park
Flights from Popular Cities to San Francisco
Cheap tickets from Port Of Spain to San FranciscoCheap flights from Manila to San FranciscoPlane tickets from Santa Maria to San FranciscoCheap flights from Molde to San FranciscoCheap flights from Nashik to San FranciscoPlane tickets from Colorado Springs to San FranciscoCheap flights from Bangui to San FranciscoCheap flights from Sao Luis to San FranciscoCheap tickets from Odesa to San FranciscoPlane tickets from Sialkot to San FranciscoCheap KLM Royal Dutch Airlines tickets to San FranciscoCheap Himalaya Airlines tickets to San FranciscoAirAsia Cambodia flight tickets to San FranciscoCheap Asky Airlines flights to San FranciscoFuzhou Airlines flight tickets to San Francisco