App
Customer Support
EUR
Find Bookings
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Cheap flight deals from St. Louis to Santo Domingo Starting at €166

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • One way
  • Round-trip
      • STL05:20 pm
        19h 20m
        1 stop
        SDQ02:40 pm
        Mon, Feb 24|St. Louis - Santo Domingo|Frontier Airlines
        €166€402
        59% OFF
        59% OFF
        €402€166

        Choose Frontier Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with Frontier Airlines departs from St. Louis Lambert International Airport on Mon, Feb 24, arriving at Las Américas International Airport. One-way Prices start from €166 including taxes and charges.

      • STL05:20 pm
        19h 20m
        1 stop
        SDQ02:40 pm
        Sat, Feb 22|St. Louis - Santo Domingo|Frontier Airlines
        €176€402
        56% OFF
        56% OFF
        €402€176

        Choose Frontier Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with Frontier Airlines departs from St. Louis Lambert International Airport on Sat, Feb 22, arriving at Las Américas International Airport. One-way Prices start from €176 including taxes and charges.

      • STL05:24 pm
        19h 25m
        1 stop
        SDQ01:49 pm
        Wed, Mar 19|St. Louis - Santo Domingo|Frontier Airlines
        €193€402
        52% OFF
        52% OFF
        €402€193

        Choose Frontier Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with Frontier Airlines departs from St. Louis Lambert International Airport on Wed, Mar 19, arriving at Las Américas International Airport. One-way Prices start from €193 including taxes and charges.

      • STL06:10 am
        18h 11m
        1 stop
        SDQ01:21 am
        Mon, Mar 10|St. Louis - Santo Domingo|Delta Air Lines
        €238
        €238

        Choose Delta Air Lines flights from St. Louis to Santo Domingo. The one-way connecting flight with Delta Air Lines departs from St. Louis Lambert International Airport on Mon, Mar 10, arriving at Las Américas International Airport. One-way Prices start from €238 including taxes and charges.

      • STL05:33 pm
        17h 12m
        1 stop
        SDQ11:45 am
        Mon, Mar 10|St. Louis - Santo Domingo|United Airlines
        €275
        €275

        Choose United Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with United Airlines departs from St. Louis Lambert International Airport on Mon, Mar 10, arriving at Las Américas International Airport. One-way Prices start from €275 including taxes and charges.

      • STL07:29 am
        15h 59m
        1 stop
        SDQ01:28 am
        Wed, Feb 19|St. Louis - Santo Domingo|American Airlines
        €294
        €294

        Choose American Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with American Airlines departs from St. Louis Lambert International Airport on Wed, Feb 19, arriving at Las Américas International Airport. One-way Prices start from €294 including taxes and charges.

      • STL08:50 am
        14h 6m
        1 stop
        SDQ12:56 am
        Sat, Feb 22|St. Louis - Santo Domingo|Delta Air Lines
        €294
        €294

        Choose Delta Air Lines flights from St. Louis to Santo Domingo. The one-way connecting flight with Delta Air Lines departs from St. Louis Lambert International Airport on Sat, Feb 22, arriving at Las Américas International Airport. One-way Prices start from €294 including taxes and charges.

      • STL05:00 pm
        28h 56m
        1 stop
        SDQ10:56 pm
        Fri, Apr 25|St. Louis - Santo Domingo|American Airlines
        €294
        €294

        Choose American Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with American Airlines departs from St. Louis Lambert International Airport on Fri, Apr 25, arriving at Las Américas International Airport. One-way Prices start from €294 including taxes and charges.

      • STL05:20 pm
        13h 9m
        1 stop
        SDQ08:29 am
        Tue, Mar 4|St. Louis - Santo Domingo|Frontier Airlines
        €298
        €298

        Choose Frontier Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with Frontier Airlines departs from St. Louis Lambert International Airport on Tue, Mar 4, arriving at Las Américas International Airport. One-way Prices start from €298 including taxes and charges.

      • STL07:05 am
        29h 4m
        1 stop
        SDQ02:09 pm
        Tue, Mar 4|St. Louis - Santo Domingo|United Airlines
        €303
        €303

        Choose United Airlines flights from St. Louis to Santo Domingo. The one-way connecting flight with United Airlines departs from St. Louis Lambert International Airport on Tue, Mar 4, arriving at Las Américas International Airport. One-way Prices start from €303 including taxes and charges.

      • STL01:00 pm
        3h 5m
        Nonstop
        SDQ02:00 pm
        Wed, Feb 26|St. Louis - Santo Domingo|Frontier Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

St. Louis to Santo Domingo Flight Time

Flight info.
Departure
Arrival
Weekly Schedule

  1. UA4566

    United Airlines

    01:03 pm

    STL

    1.5h

    02:35 pm

    ORD

    SMTWTFS
    Search

  2. UA702

    United Airlines

    03:35 pm

    ORD

    2.3h

    06:50 pm

    EWR

    SMTWTFS

  3. UA1471

    United Airlines

    09:54 pm

    EWR

    3.9h

    01:50 am

    SDQ

    SMTWTFS

  4. AA1515

    American Airlines

    05:12 am

    STL

    2.0h

    08:10 am

    CLT

    S-TWTFS
    Search

  5. AA2154

    American Airlines

    08:59 am

    CLT

    2.2h

    11:13 am

    MIA

    SMTWTFS

  6. AA1154

    American Airlines

    12:05 pm

    MIA

    2.5h

    02:35 pm

    SDQ

    SMTWTFS

  7. F92636

    Frontier Airlines

    05:20 pm

    STL

    2.5h

    08:51 pm

    MCO

    SMTWTFS
    Search

  8. F94726

    Frontier Airlines

    11:05 pm

    MCO

    2.8h

    02:54 am

    SJU

    SM-WTFS

  9. F9099

    Frontier Airlines

    11:16 am

    SJU

    1.3h

    12:32 pm

    SDQ

    -M--T--

  10. F92636

    Frontier Airlines

    05:20 pm

    STL

    2.5h

    08:51 pm

    MCO

    SMTWTFS
    Search

  11. B61405

    Jetblue Airways

    11:59 pm

    MCO

    2.6h

    02:34 am

    SDQ

    SMTWTFS

  12. UA3424

    United Airlines

    06:26 pm

    STL

    2.6h

    10:04 pm

    EWR

    SMTWTFS
    Search

  13. B6209

    Jetblue Airways

    05:01 am

    JFK

    3.8h

    08:48 am

    SDQ

    SMTWTFS

  14. CM2684

    Copa Airlines

    08:25 am

    STL

    2.1h

    11:31 am

    IAD

    SMTWTFS
    Search

  15. CM444

    Copa Airlines

    04:34 pm

    IAD

    5.0h

    08:34 pm

    PTY

    SMTWTFS

  16. CM107

    Copa Airlines

    11:13 pm

    PTY

    2.5h

    02:45 am

    SDQ

    --T-T-S

  17. DL5474

    Delta Air Lines

    09:30 am

    STL

    2.4h

    12:53 pm

    LGA

    -M---FS
    Search

  18. DL1943

    Delta Air Lines

    07:29 pm

    JFK

    4.1h

    11:35 pm

    SDQ

    SMTWTFS

  19. DL1571

    Delta Air Lines

    10:10 am

    STL

    1.6h

    12:46 pm

    ATL

    SMTWTFS
    Search

  20. DL2466

    Delta Air Lines

    05:40 pm

    ATL

    2.4h

    08:05 pm

    JFK

    SMTWTFS

  21. DL1943

    Delta Air Lines

    07:29 pm

    JFK

    4.1h

    11:35 pm

    SDQ

    SMTWTFS

  22. DL1289

    Delta Air Lines

    11:50 am

    STL

    1.6h

    02:27 pm

    DTW

    SMTWTFS
    Search

  23. DL2934

    Delta Air Lines

    04:10 pm

    DTW

    2.1h

    06:15 pm

    JFK

    SMTWTFS

  24. DL1943

    Delta Air Lines

    07:29 pm

    JFK

    4.1h

    11:35 pm

    SDQ

    SMTWTFS

  25. AA4470

    American Airlines

    12:00 pm

    STL

    1.4h

    01:24 pm

    ORD

    SMTWTFS
    Search

  26. UA702

    United Airlines

    03:35 pm

    ORD

    2.3h

    06:50 pm

    EWR

    SMTWTFS

  27. UA1471

    United Airlines

    09:54 pm

    EWR

    3.9h

    01:50 am

    SDQ

    SMTWTFS
Find more flights and airlines

When is the cheapest time to fly from St. Louis to Santo Domingo?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from St. Louis (STL) to Santo Domingo (SDQ) the cheapest?

    Airlines adjust prices for flights from St. Louis to Santo Domingo based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from St. Louis (STL) to Santo Domingo (SDQ) cost?

    According to Trip.com's data, the lowest price is around €506.

  • What is the transportation method from the main airport to downtown in Santo Domingo?

    • The distance from Las Américas International Airport to downtown is about 33 km. It takes about 50 minutes by taxi.
    • The distance from La Isabela International Airport to downtown is about 8 km. It takes about 20 minutes by taxi.

How to find a cheap flight from St. Louis to Santo Domingo

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from St. Louis to Santo Domingo. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Info | St. Louis to Santo Domingo

Cheapest nonstop flight price€166
Off-season for travelFebruary
Peak season for travelNovember
Flight distance2,976.46 km
Popular airlineAmerican Airlines

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.