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Flights from Des Moines to Buffalo

Find flight deals from Des Moines to Buffalo for the next 3 months. Book one way flights from QAR 491 or round trip flights from QAR 805.

      • DSM 11:42 AM
        6h 34m
        1 stop
        BUF 7:16 PM
        Des Moines - Buffalo | Sat, Jan 17 | American Airlines
        BUF 7:30 AM
        4h 42m
        1 stop
        DSM 11:12 AM
        Buffalo - Des Moines | Sat, Jan 24 | American Airlines
        QAR 805 QAR 1,399
        42% OFF
        42% OFF
        QAR 1,399 QAR 805
      • DSM 5:01 PM
        5h 47m
        1 stop
        BUF 11:48 PM
        Des Moines - Buffalo | Fri, Jan 30 | American Airlines
        BUF 5:12 AM
        8h 34m
        1 stop
        DSM 12:46 PM
        Buffalo - Des Moines | Mon, Feb 2 | American Airlines
        QAR 974 QAR 1,399
        30% OFF
        30% OFF
        QAR 1,399 QAR 974
      • DSM 4:25 PM
        6h 16m
        1 stop
        BUF 11:41 PM
        Des Moines - Buffalo | Thu, Jan 15 | American Airlines
        BUF 5:27 PM
        5h 44m
        1 stop
        DSM 10:11 PM
        Buffalo - Des Moines | Thu, Jan 22 | American Airlines
        QAR 1,047 QAR 1,399
        25% OFF
        25% OFF
        QAR 1,399 QAR 1,047
      • DSM 4:25 PM
        6h 16m
        1 stop
        BUF 11:41 PM
        Des Moines - Buffalo | Thu, Jan 8 | American Airlines
        BUF 6:53 PM
        5h 15m
        1 stop
        DSM 11:08 PM
        Buffalo - Des Moines | Mon, Jan 12 | American Airlines
        QAR 1,147
        18% OFF
        QAR 1,399 QAR 1,147
      • DSM 8:00 AM
        4h 24m
        1 stop
        BUF 1:24 PM
        Des Moines - Buffalo | Fri, Jan 30 | United Airlines
        BUF 8:30 AM
        7h 3m
        1 stop
        DSM 2:33 PM
        Buffalo - Des Moines | Mon, Feb 2 | United Airlines
        QAR 1,167
        17% OFF
        QAR 1,399 QAR 1,167
      • DSM 4:07 PM
        7h
        1 stop
        BUF 12:07 AM
        Des Moines - Buffalo | Thu, Dec 11 | American Airlines
        BUF 7:15 PM
        6h 22m
        1 stop
        DSM 12:37 AM
        Buffalo - Des Moines | Thu, Dec 18 | American Airlines
        QAR 1,180
        16% OFF
        QAR 1,399 QAR 1,180
      • DSM 6:24 AM
        4h 21m
        1 stop
        BUF 11:45 AM
        Des Moines - Buffalo | Thu, Jan 29 | Delta Air Lines
        BUF 6:03 AM
        4h 38m
        1 stop
        DSM 9:41 AM
        Buffalo - Des Moines | Sun, Feb 1 | Delta Air Lines
        QAR 1,196
        14% OFF
        QAR 1,399 QAR 1,196
      • DSM 6:40 AM
        4h 22m
        1 stop
        BUF 12:02 PM
        Des Moines - Buffalo | Thu, Jan 1 | American Airlines
        BUF 5:12 AM
        8h 34m
        1 stop
        DSM 12:46 PM
        Buffalo - Des Moines | Thu, Jan 8 | American Airlines
        QAR 1,226
        12% OFF
        QAR 1,399 QAR 1,226
      • DSM 8:00 AM
        4h 24m
        1 stop
        BUF 1:24 PM
        Des Moines - Buffalo | Thu, Jan 8 | United Airlines
        BUF 8:30 AM
        7h 3m
        1 stop
        DSM 2:33 PM
        Buffalo - Des Moines | Thu, Jan 15 | United Airlines
        QAR 1,234
        12% OFF
        QAR 1,399 QAR 1,234
      • DSM 3:00 PM
        7h 59m
        1 stop
        BUF 11:59 PM
        Des Moines - Buffalo | Sat, Dec 13 | Delta Air Lines
        BUF 6:00 AM
        5h 38m
        1 stop
        DSM 10:38 AM
        Buffalo - Des Moines | Sun, Dec 14 | Delta Air Lines
        QAR 1,259
        10% OFF
        QAR 1,399 QAR 1,259
      • DSM 1:00 PM
        17h 25m
        1 stop
        BUF Invalid Date
        Des Moines - Buffalo | Sat, Dec 13 | Normal Airline
        BUF 3:00 PM
        6h
        Nonstop
        DSM 4:00 PM
        Buffalo - Des Moines | Mon, Dec 15 | Normal Airline
        Find More Flights
        Find More Flights
      • DSM 6:14 PM
        14h 7m
        1 stop
        BUF 9:21 AM
        Des Moines - Buffalo | Wed, Jan 14 | Allegiant Air
        QAR 491 QAR 725
        32% OFF
        32% OFF
        QAR 725 QAR 491
      • DSM 5:16 PM
        5h 12m
        1 stop
        BUF 11:28 PM
        Des Moines - Buffalo | Thu, Jan 22 | Delta Air Lines
        QAR 511 QAR 725
        30% OFF
        30% OFF
        QAR 725 QAR 511
      • DSM 11:14 AM
        10h 27m
        1 stop
        BUF 10:41 PM
        Des Moines - Buffalo | Tue, Dec 23 | Frontier Airlines
        QAR 523 QAR 725
        28% OFF
        28% OFF
        QAR 725 QAR 523
      • DSM 8:00 AM
        10h 28m
        1 stop
        BUF 7:28 PM
        Des Moines - Buffalo | Mon, Jan 5 | Allegiant Air
        QAR 548
        25% OFF
        QAR 725 QAR 548
      • DSM 6:24 AM
        4h 18m
        1 stop
        BUF 11:42 AM
        Des Moines - Buffalo | Sat, Jan 17 | Delta Air Lines
        QAR 558
        23% OFF
        QAR 725 QAR 558
      • DSM 5:21 PM
        5h 7m
        1 stop
        BUF 11:28 PM
        Des Moines - Buffalo | Tue, Dec 23 | Delta Air Lines
        QAR 560
        23% OFF
        QAR 725 QAR 560
      • DSM 5:15 PM
        5h 42m
        1 stop
        BUF 11:57 PM
        Des Moines - Buffalo | Tue, Jan 6 | Delta Air Lines
        QAR 564
        22% OFF
        QAR 725 QAR 564
      • DSM 4:07 PM
        7h
        1 stop
        BUF 12:07 AM
        Des Moines - Buffalo | Thu, Dec 11 | American Airlines
        QAR 594
        18% OFF
        QAR 725 QAR 594
      • DSM 5:16 PM
        5h 42m
        1 stop
        BUF 11:58 PM
        Des Moines - Buffalo | Mon, Jan 12 | Delta Air Lines
        QAR 610
        16% OFF
        QAR 725 QAR 610
      • DSM 8:00 AM
        4h 24m
        1 stop
        BUF 1:24 PM
        Des Moines - Buffalo | Thu, Jan 8 | United Airlines
        QAR 653
        10% OFF
        QAR 725 QAR 653
      • DSM 1:00 PM
        17h 25m
        1 stop
        BUF Invalid Date
        Des Moines - Buffalo | Sat, Dec 13 | Normal Airline
        Find More Flights
        Find More Flights

Displayed flight fares from Des Moines to Buffalo are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Flying from Des Moines to Buffalo

The distance between Des Moines and Buffalo is approximately 1,236.99 km. Based on Trip.com's data travel demand peaks in July. The off-season for travel is September.

Cheapest one-way flight priceQAR 491
Cheapest round-trip ticket priceQAR 805
Off-season for travelSeptember
Peak season for travelJuly
Flight distance1,236.99 km

When is the cheapest time to fly from Des Moines to Buffalo?

The cheapest time for Des Moines to Buffalo flights: Jan 11 to Jan 18 — one way flight prices from QAR 490.

Cheapest flights
From price
Search
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
  • 18
  • 815
  • 1522

  • Mar

    221
Displayed fare trends are based on Trip.com's aggregated average of the lowest flight prices from Des Moines to Buffalo, calculated over the upcoming 10 weeks.

Frequently Asked Questions

  • What are the cheapest flights from Des Moines to Buffalo (DSM-BUF)?

    Based on Trip.com data, Allegiant Air offers one-way fares as low as QAR 491 on Cheapest nonstop routes (e.g. DSM to BUF on Wed, Jan 14), while American Airlines offers Cheapest nonstop round-trips from QAR 805 departing on Sat, Jan 17 and returning on Sat, Jan 24.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Des Moines to Buffalo is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Des Moines to Buffalo, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Jan 14, with one-way flights priced at just QAR 491.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Allegiant Air.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Buffalo travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Des Moines to Buffalo is September, when demand for travel is lower.
  • After crunching the numbers on our December flight calendar, it's currently cheapest to fly from Des Moines to Buffalo on December 11, 2025 with American Airlines, with prices starting at QAR 1,179.
  • The time difference between Buffalo and Des Moines is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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