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Cheap flight deals from Chicago to Sao Tome Island Starting at €1,562

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • Round-trip
      • ORD04:18 pm
        18h 57m
        2 stops
        TMS05:15 pm
        Fri, Feb 28|Chicago - Sao Tome Island|Iberia
        TMS07:25 pm
        48h 30m
        2 stops
        ORD01:55 pm
        Sun, Mar 2|Sao Tome Island - Chicago|TAP Air Portugal
        €1,562€5,870
        73% OFF
        73% OFF
        €5,870€1,562

        Choose Iberia flights from Chicago to Sao Tome Island. The one-way connecting flight with Iberia departs from O'Hare International Airport on Fri, Feb 28-Sun, Mar 2, arriving at São Tomé International Airport. One-way Prices start from €1,562 including taxes and charges.

      • ORD03:35 pm
        19h 40m
        2 stops
        TMS05:15 pm
        Fri, Feb 28|Chicago - Sao Tome Island|United Airlines
        TMS07:25 pm
        30h 40m
        2 stops
        ORD08:05 pm
        Sun, Mar 2|Sao Tome Island - Chicago|TAP Air Portugal
        €1,654€5,870
        72% OFF
        72% OFF
        €5,870€1,654

        Choose United Airlines flights from Chicago to Sao Tome Island. The one-way connecting flight with United Airlines departs from O'Hare International Airport on Fri, Feb 28-Sun, Mar 2, arriving at São Tomé International Airport. One-way Prices start from €1,654 including taxes and charges.

      • ORD11:53 am
        23h 22m
        2 stops
        TMS05:15 pm
        Fri, Feb 28|Chicago - Sao Tome Island|TAP Air Portugal
        TMS07:25 pm
        29h 55m
        2 stops
        ORD07:20 pm
        Sun, Mar 2|Sao Tome Island - Chicago|TAP Air Portugal
        €2,219€5,870
        62% OFF
        62% OFF
        €5,870€2,219

        Choose TAP Air Portugal flights from Chicago to Sao Tome Island. The one-way connecting flight with TAP Air Portugal departs from O'Hare International Airport on Fri, Feb 28-Sun, Mar 2, arriving at São Tomé International Airport. One-way Prices start from €2,219 including taxes and charges.

      • ORD08:05 pm
        40h 10m
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|Swiss Airlines
        TMS07:25 pm
        46h 45m
        2 stops
        ORD12:10 pm
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,281
        €2,281

        Choose Swiss Airlines flights from Chicago to Sao Tome Island. The one-way connecting flight with Swiss Airlines departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,281 including taxes and charges.

      • ORD04:55 pm
        43h 20m
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|Lufthansa
        TMS07:25 pm
        46h 45m
        2 stops
        ORD12:10 pm
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,304
        €2,304

        Choose Lufthansa flights from Chicago to Sao Tome Island. The one-way connecting flight with Lufthansa departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,304 including taxes and charges.

      • ORD12:55 pm
        47h 20m
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|Turkish Airlines
        TMS07:25 pm
        43h 25m
        2 stops
        ORD09:50 am
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,351
        €2,351

        Choose Turkish Airlines flights from Chicago to Sao Tome Island. The one-way connecting flight with Turkish Airlines departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,351 including taxes and charges.

      • ORD05:15 pm
        43h
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|TAP Air Portugal
        TMS07:25 pm
        42h
        2 stops
        ORD08:25 am
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,381
        €2,381

        Choose TAP Air Portugal flights from Chicago to Sao Tome Island. The one-way connecting flight with TAP Air Portugal departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,381 including taxes and charges.

      • ORD07:00 pm
        41h 15m
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|United Airlines
        TMS07:25 pm
        41h 5m
        2 stops
        ORD07:30 am
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,431
        €2,431

        Choose United Airlines flights from Chicago to Sao Tome Island. The one-way connecting flight with United Airlines departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,431 including taxes and charges.

      • ORD08:11 am
        28h 44m
        2 stops
        TMS05:55 pm
        Thu, Mar 20|Chicago - Sao Tome Island|American Airlines
        TMS07:25 pm
        43h 35m
        2 stops
        ORD10:00 am
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,530
        €2,530

        Choose American Airlines flights from Chicago to Sao Tome Island. The one-way connecting flight with American Airlines departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,530 including taxes and charges.

      • ORD07:30 pm
        40h 45m
        2 stops
        TMS05:15 pm
        Thu, Mar 20|Chicago - Sao Tome Island|Finnair
        TMS07:25 pm
        27h 15m
        2 stops
        ORD05:40 pm
        Fri, Mar 28|Sao Tome Island - Chicago|TAP Air Portugal
        €2,787
        €2,787

        Choose Finnair flights from Chicago to Sao Tome Island. The one-way connecting flight with Finnair departs from O'Hare International Airport on Thu, Mar 20-Fri, Mar 28, arriving at São Tomé International Airport. One-way Prices start from €2,787 including taxes and charges.

      • CHI01:00 pm
        3h 5m
        Nonstop
        TMS02:00 pm
        Wed, Feb 26|Chicago - Sao Tome Island|Iberia
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Chicago to Sao Tome Island Flight Time

Flight info.
Departure
Arrival
Weekly Schedule

  1. UA702

    United Airlines

    03:35 pm

    ORD

    2.3h

    06:50 pm

    EWR

    SMTWTFS
    Search

  2. UA064

    United Airlines

    08:35 pm

    EWR

    6.8h

    08:20 am

    LIS

    SMTWTFS

  3. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  4. IB4351

    Iberia

    04:18 pm

    ORD

    2.0h

    07:17 pm

    PHL

    S--WT-S
    Search

  5. IB4918

    Iberia

    09:15 pm

    PHL

    6.8h

    09:05 am

    LIS

    SMTWTFS

  6. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  7. IB342

    Iberia

    04:30 pm

    ORD

    8.4h

    07:55 am

    MAD

    SMTWTFS
    Search

  8. IB1141

    Iberia

    11:25 am

    MAD

    1.4h

    11:50 am

    LIS

    SMTWTFS

  9. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  10. AY5760

    Finnair

    05:35 pm

    ORD

    7.8h

    07:25 am

    LHR

    SMTWTFS
    Search

  11. AY5895

    Finnair

    01:30 pm

    LHR

    2.8h

    04:20 pm

    LIS

    SMTWTF-

  12. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  13. UA953

    United Airlines

    05:50 pm

    ORD

    8.8h

    09:40 am

    MUC

    SMTWTFS
    Search

  14. LH1778

    Lufthansa

    11:00 am

    MUC

    3.3h

    01:20 pm

    LIS

    SMTWTFS

  15. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  16. LX009

    Swiss Airlines

    07:05 pm

    ORD

    8.8h

    10:50 am

    ZRH

    SMTWTFS
    Search

  17. LX2084

    Swiss Airlines

    12:35 pm

    ZRH

    3.0h

    02:35 pm

    LIS

    SMTWTFS

  18. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  19. AA2345

    American Airlines

    07:50 am

    ORD

    1.9h

    10:44 am

    DCA

    SMTWTFS
    Search

  20. TP232

    TAP Air Portugal

    05:45 pm

    IAD

    7.3h

    06:05 am

    LIS

    -M---F-

  21. TP1527

    TAP Air Portugal

    09:55 am

    LIS

    8.7h

    05:35 pm

    TMS

    --T-T-S

  22. BA296

    British Airways

    09:15 pm

    ORD

    7.8h

    11:00 am

    LHR

    SMTWTFS
    Search

  23. BA502

    British Airways

    03:05 pm

    LHR

    2.8h

    05:55 pm

    LIS

    SMTWTFS

  24. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  25. AA3056

    American Airlines

    10:07 am

    ORD

    3.2h

    02:17 pm

    MIA

    SMTWTFS
    Search

  26. TP224

    TAP Air Portugal

    04:35 pm

    MIA

    8.3h

    05:50 am

    LIS

    S-TWTFS

  27. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-

  28. TP8481

    TAP Air Portugal

    10:36 am

    ORD

    2.3h

    01:53 pm

    EWR

    SMTWTFS
    Search

  29. TP202

    TAP Air Portugal

    05:35 pm

    EWR

    6.9h

    05:30 am

    LIS

    SMTW-F-

  30. TP1531

    TAP Air Portugal

    11:40 am

    LIS

    6.7h

    05:20 pm

    TMS

    -----F-
Find more flights and airlines

When is the cheapest time to fly from Chicago to Sao Tome Island?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from Chicago (CHI) to Sao Tome Island (TMS) the cheapest?

    Airlines adjust prices for flights from Chicago to Sao Tome Island based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Chicago (CHI) to Sao Tome Island (TMS) cost?

    According to Trip.com's data, the lowest price is around €1,078.

  • What is the transportation method from the main airport to downtown in Sao Tome Island?

    • The distance from São Tomé International Airport to downtown is about 5 km. It takes about 20 minutes by taxi.

How to find a cheap flight from Chicago to Sao Tome Island

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Chicago to Sao Tome Island. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Info | Chicago to Sao Tome Island

Off-season for travelFebruary
Peak season for travelJanuary
Flight distance10,339.58 km
Popular airlineAmerican Airlines

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