App
Customer Support
GBP
Find Bookings
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Cheap flight deals from Charleston to Knoxville Starting at £233

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • Round-trip
      • CRW05:50 pm
        5h 57m
        1 stop
        TYS11:47 pm
        Wed, Feb 26|Charleston - Knoxville|Delta Air Lines
        TYS05:45 am
        5h 2m
        1 stop
        CRW10:47 am
        Tue, Mar 4|Knoxville - Charleston|Delta Air Lines
        £233£441
        47% OFF
        47% OFF
        £441£233

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Wed, Feb 26-Tue, Mar 4, arriving at Mcghee Tyson Airport. One-way Prices start from £233 including taxes and charges.

      • CRW05:50 pm
        5h 57m
        1 stop
        TYS11:47 pm
        Wed, Feb 19|Charleston - Knoxville|Delta Air Lines
        TYS10:03 am
        3h 54m
        1 stop
        CRW01:57 pm
        Tue, Feb 25|Knoxville - Charleston|Delta Air Lines
        £235£441
        47% OFF
        47% OFF
        £441£235

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Wed, Feb 19-Tue, Feb 25, arriving at Mcghee Tyson Airport. One-way Prices start from £235 including taxes and charges.

      • CRW06:00 am
        3h 16m
        1 stop
        TYS09:16 am
        Thu, Feb 27|Charleston - Knoxville|Delta Air Lines
        TYS12:08 pm
        5h 2m
        1 stop
        CRW05:10 pm
        Wed, Mar 5|Knoxville - Charleston|Delta Air Lines
        £270£441
        39% OFF
        39% OFF
        £441£270

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Thu, Feb 27-Wed, Mar 5, arriving at Mcghee Tyson Airport. One-way Prices start from £270 including taxes and charges.

      • CRW02:37 pm
        5h 27m
        1 stop
        TYS08:04 pm
        Thu, Feb 20|Charleston - Knoxville|Delta Air Lines
        TYS05:00 pm
        4h 38m
        1 stop
        CRW09:38 pm
        Wed, Feb 26|Knoxville - Charleston|Delta Air Lines
        £272
        £272

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Thu, Feb 20-Wed, Feb 26, arriving at Mcghee Tyson Airport. One-way Prices start from £272 including taxes and charges.

      • CRW05:50 pm
        5h 57m
        1 stop
        TYS11:47 pm
        Mon, Feb 24|Charleston - Knoxville|Delta Air Lines
        TYS05:45 am
        5h 2m
        1 stop
        CRW10:47 am
        Sun, Mar 2|Knoxville - Charleston|Delta Air Lines
        £308
        £308

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Mon, Feb 24-Sun, Mar 2, arriving at Mcghee Tyson Airport. One-way Prices start from £308 including taxes and charges.

      • CRW11:37 am
        4h 57m
        1 stop
        TYS04:34 pm
        Sat, Feb 22|Charleston - Knoxville|Delta Air Lines
        TYS07:00 am
        3h 47m
        1 stop
        CRW10:47 am
        Fri, Feb 28|Knoxville - Charleston|Delta Air Lines
        £309
        £309

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Sat, Feb 22-Fri, Feb 28, arriving at Mcghee Tyson Airport. One-way Prices start from £309 including taxes and charges.

      • CRW06:00 am
        5h 23m
        1 stop
        TYS11:23 am
        Tue, Feb 25|Charleston - Knoxville|Delta Air Lines
        TYS07:17 pm
        21h 53m
        1 stop
        CRW05:10 pm
        Mon, Mar 3|Knoxville - Charleston|Delta Air Lines
        £380
        £380

        Choose Delta Air Lines flights from Charleston to Knoxville. The one-way connecting flight with Delta Air Lines departs from Yeager Airport on Tue, Feb 25-Mon, Mar 3, arriving at Mcghee Tyson Airport. One-way Prices start from £380 including taxes and charges.

      • CRW07:05 am
        9h 49m
        1 stop
        TYS04:54 pm
        Wed, Feb 19|Charleston - Knoxville|United Airlines
        TYS02:00 pm
        26h 44m
        1 stop
        CRW04:44 pm
        Tue, Feb 25|Knoxville - Charleston|United Airlines
        £383
        £383

        Choose United Airlines flights from Charleston to Knoxville. The one-way connecting flight with United Airlines departs from Yeager Airport on Wed, Feb 19-Tue, Feb 25, arriving at Mcghee Tyson Airport. One-way Prices start from £383 including taxes and charges.

      • CRW07:05 am
        15h 55m
        1 stop
        TYS11:00 pm
        Thu, Feb 27|Charleston - Knoxville|United Airlines
        TYS07:00 am
        13h 53m
        1 stop
        CRW08:53 pm
        Wed, Mar 5|Knoxville - Charleston|United Airlines
        £384
        £384

        Choose United Airlines flights from Charleston to Knoxville. The one-way connecting flight with United Airlines departs from Yeager Airport on Thu, Feb 27-Wed, Mar 5, arriving at Mcghee Tyson Airport. One-way Prices start from £384 including taxes and charges.

      • CRW07:05 am
        9h 49m
        1 stop
        TYS04:54 pm
        Tue, Feb 25|Charleston - Knoxville|United Airlines
        TYS07:25 pm
        21h 19m
        2 stops
        CRW04:44 pm
        Mon, Mar 3|Knoxville - Charleston|United Airlines
        £384
        £384

        Choose United Airlines flights from Charleston to Knoxville. The one-way connecting flight with United Airlines departs from Yeager Airport on Tue, Feb 25-Mon, Mar 3, arriving at Mcghee Tyson Airport. One-way Prices start from £384 including taxes and charges.

      • CRW01:00 pm
        3h 5m
        Nonstop
        TYS02:00 pm
        Sun, Feb 23|Charleston - Knoxville|Delta Air Lines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Charleston to Knoxville Flight Time

Flight info.
Departure
Arrival
Weekly Schedule

  1. DL3811

    Delta Air Lines

    03:25 pm

    CRW

    1.6h

    05:01 pm

    ATL

    SMTWT-S
    Search

  2. DL3072

    Delta Air Lines

    10:50 pm

    ATL

    0.9h

    11:44 pm

    TYS

    SMTWTFS

  3. AA5153

    American Airlines

    05:39 am

    CRW

    1.3h

    06:59 am

    DCA

    SMTWTFS
    Search

  4. AA1200

    American Airlines

    09:28 am

    DCA

    2.2h

    10:40 am

    ORD

    SMTWT-S

  5. UA5379

    United Airlines

    02:10 pm

    ORD

    1.7h

    04:54 pm

    TYS

    SMTWT--

  6. DL3805

    Delta Air Lines

    06:24 am

    CRW

    1.7h

    08:04 am

    ATL

    SMTWTFS
    Search

  7. DL857

    Delta Air Lines

    10:25 am

    ATL

    1.0h

    11:23 am

    TYS

    SMTWTFS

  8. DL3805

    Delta Air Lines

    06:24 am

    CRW

    1.7h

    08:04 am

    ATL

    SMTWTFS
    Search

  9. DL1418

    Delta Air Lines

    08:20 am

    ATL

    0.9h

    09:16 am

    TYS

    SMTWT-S

  10. DL5105

    Delta Air Lines

    06:40 pm

    CRW

    1.7h

    08:22 pm

    ATL

    SMTWT-S
    Search

  11. DL5203

    Delta Air Lines

    06:00 pm

    ATL

    1.0h

    07:00 pm

    TYS

    SMTWT-S

  12. DL5105

    Delta Air Lines

    06:40 pm

    CRW

    1.7h

    08:22 pm

    ATL

    SMTWT-S
    Search

  13. DL4886

    Delta Air Lines

    05:38 pm

    ATL

    1.0h

    06:37 pm

    TYS

    SMTWTFS

  14. UA5801

    United Airlines

    07:00 am

    CRW

    2.0h

    07:58 am

    ORD

    SMTWTFS
    Search

  15. UA3592

    United Airlines

    02:10 pm

    ORD

    1.7h

    04:54 pm

    TYS

    -----F-

  16. UA5801

    United Airlines

    07:00 am

    CRW

    2.0h

    07:58 am

    ORD

    SMTWTFS
    Search

  17. UA5379

    United Airlines

    02:10 pm

    ORD

    1.7h

    04:54 pm

    TYS

    SMTWT--

  18. UA5801

    United Airlines

    07:00 am

    CRW

    2.0h

    07:58 am

    ORD

    SMTWTFS
    Search

  19. UA4505

    United Airlines

    10:35 am

    ORD

    1.8h

    01:22 pm

    TYS

    SMTWTFS

  20. DL4850

    Delta Air Lines

    11:37 am

    CRW

    1.5h

    01:05 pm

    ATL

    SMTWTFS
    Search

  21. DL5472

    Delta Air Lines

    02:12 pm

    ATL

    0.9h

    03:08 pm

    TYS

    SMTWTFS
Find more flights and airlines

When is the cheapest time to fly from Charleston to Knoxville?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from Charleston (CRW) to Knoxville (TYS) the cheapest?

    Airlines adjust prices for flights from Charleston to Knoxville based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Charleston (CRW) to Knoxville (TYS) cost?

    According to Trip.com's data, the lowest price is around £444.

How to find a cheap flight from Charleston to Knoxville

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Charleston to Knoxville. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Info | Charleston to Knoxville

Off-season for travelDecember
Peak season for travelJanuary
Flight distance355.65 km
Popular airlineAmerican Airlines

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.